Biocompatibility test of microfilled resins and composites for core use in vitro.

Experiments were carried out in an in vitro environment by the cell colony forming method in order to study the cytotoxicity to HeLa cells of set specimens of 3 MFRs and 4 composites for core use. In the experiment each of the specimens was extracted in a tissue culture medium for 2 weeks in dynamic environment with a specimen freely moving. With both MFRs and the composites for core use cytotoxicity ranging from moderate to strong was noted initially, followed by subsequent loss of cytotoxicity at the end of experiments, which is quite similar to that of the conventional composites tested earlier.